The short answer
Insomnia is not listed as a common side effect on the labels for Ozempic, Wegovy, Mounjaro, Zepbound, or Foundayo. Fatigue is. On Wegovy, 11% of people felt tired or weak, compared with 5% on placebo.1
When sleep gets worse on these medicines, the cause is often something around the drug: hunger or nausea at night, reflux, low blood sugar, or a routine that has changed. Look at each one, keep a steady bedtime, and talk to your doctor if it does not get better.
"Is it my GLP-1, or something else?"
I have a lot of friends on Ozempic, Mounjaro, and Zepbound. Most are thrilled with how they feel. But some have asked me the same thing: "I am exhausted all day, but I cannot sleep at night. Is it my medicine?"
My answer is always the same. It could be the GLP-1, but it could be other things too. You have to look at all of the things that affect your sleep, one by one.
What the labels say about sleep and fatigue
Ozempic and Wegovy are the same medicine (semaglutide). Mounjaro and Zepbound are the same medicine (tirzepatide). Foundayo (orforglipron) is a daily pill approved in April 2026.3 Here is what their official labels report.
| Medicine | Tired or weak | Insomnia |
|---|---|---|
| Wegovy (same medicine as Ozempic) | 11% vs 5% on placebo | Not listed |
| Zepbound (same medicine as Mounjaro) | 5% to 7% vs 3% on placebo | Not listed |
| Foundayo (daily pill) | Listed as common (5% or more) | Not listed |
These numbers come from weight loss trials. Ozempic and Mounjaro were studied in people with diabetes, at different doses, so their numbers can differ.1,2,3
So feeling tired is a real, known side effect. Not sleeping well is not on the list. That is why it pays to look at what else changed. For more on low energy, read why GLP-1s can make you tired.
Five things that can keep you up on a GLP-1
Cause 1
Hunger at night
Signs: you eat much less during the day, then wake up hungry or cannot settle down.
What to try: ask your care team about a small, protein rich snack in the evening, and keep regular meal times.
Cause 2
Nausea
Signs: you feel sick to your stomach in the evening, often after a dose increase.
What to try: eat smaller meals, stop eating a few hours before bed, and tell your prescriber if nausea keeps you up.
Cause 3
Reflux
Signs: burning in your chest or throat when you lie down. Reflux is listed as a side effect on the Zepbound and Foundayo labels.2,3
What to try: finish dinner earlier, raise the head of your bed, and ask your doctor or pharmacist about it.
Cause 4
Low blood sugar
Signs: you wake up sweaty, shaky, or with a racing heart. This is most likely if you also take insulin or a sulfonylurea for diabetes. On Zepbound, 10% of people who also took a sulfonylurea had low blood sugar, compared with 2% of people who did not.2
What to try: check your blood sugar if you can, and call your doctor. Your diabetes medicine may need to change.
Cause 5
A routine that has changed
Signs: new workouts, later meals, a moving bedtime, or more screen time at night.
What to try: keep the same bedtime and wake time, and do not push your workouts too hard while you adjust. See tired but cannot sleep.
What I tell friends to do
Stay as close to your routine as you can. If a supplement helps you relax and wind down, it can support that routine. Take it at the same time every night, before bed.
If you use melatonin, low dose is best. The last thing you want, when you already feel tired, is something that adds to your fatigue the next day.
There is research behind that. In adults over 50, a 3 mg dose of melatonin kept levels high into the next day, while 0.3 mg was enough to bring night levels back to normal.4 Read how much melatonin should I take to learn more.
- Keep a sleep diary for two weeks. Write down your dose day, meals, symptoms at night, and how you feel in the morning.
- Look for a pattern. Is it worse after a dose increase, a late meal, or a workout?
- Fix what you can. Earlier dinner, a steady bedtime, phone out of the bedroom.
- Ask your pharmacist before adding melatonin or any supplement.
- Talk to your prescriber if it lasts. Do not stop or change your medicine on your own.
Can I take melatonin with Ozempic, Zepbound, or Foundayo?
The labels for these medicines do not list melatonin as an interaction. But they do say these drugs can change how well other pills are absorbed, so care is needed with any medicine you take by mouth.1,2 That is why the best answer is to check with your pharmacist first.
Important for women on birth control pills
The Zepbound label advises women on birth control pills to switch to a method that is not a pill, or add a backup method, for 4 weeks after starting and for 4 weeks after each dose increase.2 Mounjaro is the same medicine. Ask your doctor what this means for you. In perimenopause or menopause? Read GLP-1s in menopause: night sweats, HRT, and sleep.
Are GLP-1s peptides?
Most of them are. A peptide is a short chain of amino acids, the building blocks of protein. Semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are peptides made to act like natural gut hormones. That is one reason most of them are given as a shot.
Foundayo is different. It is a small molecule pill, not a peptide, and it can be taken with or without food or water.5
You may also see "research peptides" sold online, including products called retatrutide. These are not approved medicines, and no one checks what is in them. Read retatrutide and sleep to learn why that matters.
Talk to your doctor if
- Your sleep has been poor for more than a few weeks.
- You wake up sweaty, shaky, or with a racing heart.
- Nausea, vomiting, or reflux keeps you up at night.
- You snore loudly or stop breathing in your sleep.
- You feel low, anxious, or not yourself.
Where Driffly fits
A low dose for a steady routine
Driffly is not made for GLP-1 medicines and has not been studied with them. But if you and your pharmacist decide melatonin fits your bedtime routine, a low dose is where I would start. That is why I chose 1 mg of melatonin for Driffly, with valerian root, lavender, chamomile, and hibiscus to support a calm wind down.*
- 1 mg of melatonin, the same in every strip.
- Melts on your tongue. No water and no sugar.
- Take it 30 minutes before bed, at the same time every night.
Every order comes with a 30 night money back guarantee.
Common questions about GLP-1s and sleep
Can Ozempic cause insomnia?
Insomnia is not listed as a common side effect on the label for Wegovy, which is the same medicine as Ozempic. Feeling tired is.1 If you cannot sleep, look at hunger, nausea, reflux, and your routine, and talk to your doctor.
Does Zepbound cause insomnia?
Insomnia is not listed on the Zepbound label. Fatigue is, in 5% to 7% of people, compared with 3% on placebo.2
Why am I so tired on Mounjaro?
Mounjaro is the same medicine as Zepbound, which lists fatigue as a side effect.2 Eating much less, poor sleep, and new workouts can add to it. If it does not get better, talk to your prescriber. Read GLP-1 fatigue for six common reasons.
Does Foundayo make you tired?
Fatigue is listed as one of the common side effects of Foundayo, along with headache and stomach side effects.3 Read Foundayo side effects for the full list.
Can I take melatonin with a GLP-1?
The labels do not list melatonin as an interaction, but these medicines can affect how pills are absorbed.1,2 Ask your pharmacist first. If they say it is fine, a low dose at the same time each night is a sensible start.
Are GLP-1 medicines peptides?
Semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are peptides. Foundayo is not. It is a small molecule pill.5
Can a GLP-1 help sleep apnea?
Yes, for some people. Zepbound is FDA approved to treat moderate to severe obstructive sleep apnea in adults with obesity.2
Sources
- Wegovy (semaglutide) injection, prescribing information. US Food and Drug Administration label, 2024.
- Zepbound (tirzepatide) injection, prescribing information. US Food and Drug Administration label, 2026.
- Drugs.com. Foundayo (orforglipron) FDA approval history and prescribing summary. 2026.
- Zhdanova IV, Wurtman RJ, Regan MM, et al. Melatonin treatment for age-related insomnia. The Journal of Clinical Endocrinology and Metabolism. 2001;86(10):4727-4730.
- Healio. FDA approves orforglipron, an oral GLP-1 for adults with obesity. April 1, 2026.
Tyler Smith, RN, BSN, BA is a registered nurse and the founder of Driffly. He writes and reviews the articles in the sleep education hub. About Tyler
The author is the founder of Driffly, which sells the product mentioned in this article. Driffly does not sell GLP-1 medicines or any prescription medicine. This article is for education and is not medical advice. Do not stop or change any medicine without talking to your doctor. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.